2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Neuropeptide Y Receptor

Neuropeptide Y Receptor

NPY receptor

Neuropeptide Y Receptor

Related Products

PDF 0.79 MB

Neuropeptide Y receptors belong G protein-coupled receptor superfamily and comprise various subtypes. There are currently five cloned NPY receptor subtypes in mammals, termed Y1, Y2, Y4, Y5, and Y6. Neuropeptide Y receptors mediate a variety of physiological responses including feeding and vasoconstriction.

Subtypes Y1, Y2, Y4 and Y5 are expressed in humans. They are present mainly in the central and peripheral nervous systems as well as other tissues, such as the cardiovascular system. Their physiologic ligands are the neurotransmitter Neuropeptide Y and the 2 hormones peptide YY (PYY) and pancreatic polypeptide (PP).

Neuropeptide Y and its receptors regulate important biological and pathophysiological functions, such as blood pressure, neuroendocrine secretions, seizures, neuronal excitability and neuroplasticity.

Neuropeptide Y Receptor Isoform Specific Products:

Neuropeptide Y Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1128
    Galanin (swine)
    		Agonist 98.99%
    Galanin (swine), a neuropeptide, consists of 29 amino acids and contains a C-terminal amidated glycine. Galanin (swine) inhibits basal and stimulated insulin secretion both in vivo and in vitro under a variety of experimental conditions. Galanin (swine) is a galanin receptor agonist with pKis of 9.63, 9.49, 9.02, 8.98, 8.01 and 8.14 at human GAL1, rat GAL1, human GAL2, rat GAL2, human GAL3 and rat GAL3 respectively.
    Galanin (swine)
  • HY-RS09511
    NPY1R Human Pre-designed siRNA Set A
    		Inhibitor

    NPY1R Human Pre-designed siRNA Set A contains three designed siRNAs for NPY1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    NPY1R Human Pre-designed siRNA Set A
  • HY-156922
    NPY-5 receptor antagonist-1
    		Antagonist 99.86%
    NPY-5 receptor antagonist-1 (Example 57) is a NPY-5 receptor antagonist (Ki: < 1 μM). NPY-5 receptor antagonist-1 can be used for research of obesity, feeding disorders, as well as other neurological diseases.
    NPY-5 receptor antagonist-1
  • HY-P1428A
    RFRP-1(human) TFA
    		Agonist
    RFRP-1(human) TFA is a potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats.
    RFRP-1(human) TFA
  • HY-RS09521
    Npy5r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Npy5r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npy5r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Npy5r Mouse Pre-designed siRNA Set A
  • HY-P11044
    GEP12
    		Agonist
    GEP12 is a GLP-1R/Y1-R/Y2-R tri-receptor agonist peptide with an EC50 of 17.3 nM and an IC50 of 19.2 nM for receptor binding. GEP12 may promote glycemic control and weight loss.
    GEP12
  • HY-P3877
    (Leu31,Pro34)-Peptide YY (human)
    		Agonist
    (Leu31,Pro34)-Peptide YY (human) is a Peptide YY (HY-P1514) derivative and is a potent and selective Y1 agonist with a KD of 1.0 nM.
    (Leu31,Pro34)-Peptide YY (human)
  • HY-RS09514
    NPY2R Human Pre-designed siRNA Set A
    		Inhibitor

    NPY2R Human Pre-designed siRNA Set A contains three designed siRNAs for NPY2R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    NPY2R Human Pre-designed siRNA Set A
  • HY-P5757
    (D-Trp32)-Neuropeptide Y (porcine)
    		Agonist
    (D-Trp32)-Neuropeptide Y (porcine) is a highly selective neuropeptide Y (NPY) Y5 receptor agonist. (D-Trp32)-Neuropeptide Y (porcine) has orexigenic activity and inhibits Forskolin (HY-15371)-stimulated cAMP formation.
    (D-Trp32)-Neuropeptide Y (porcine)
  • HY-107725A
    BIBO3304 diTFA
    		Inhibitor
    BIBO3304 (diTFA) is an orally effective and selective neuropeptide Y (NPY) Y1 receptor antagonist. BIBO3304 (diTFA) has a high affinity for both human and rat Y1 receptors, with IC50 values of 0.38 and 0.72 nM, respectively. BIBO3304 (diTFA) promotes bone-tendon healing through the Wnt/β-catenin signaling pathway.
    BIBO3304 diTFA
  • HY-149593
    VU0506013
    		Modulator
    VU0506013 is a selective positive allosteric modulator of Y4R (KB = 34.9 nM). VU0506013 can be used in the development of anti-obesity agents targeting Y4R.
    VU0506013
  • HY-P1537
    Pancreatic Polypeptide, bovine
    		Agonist
    Pancreatic Polypeptide, bovine, a 36-amino acid, straight chain polypeptide derived primarily from the pancreas, inhibits secretin- and cholecystokinin-stimulated pancreatic secretion; Pancreatic Polypeptide, bovine acts as an agonist of NPY receptor, with high affinity at NPYR4.
    Pancreatic Polypeptide, bovine
  • HY-W012999R
    Tiglic acid (Standard)
    Tiglic acid (Standard) is the analytical standard of Tiglic acid (HY-W012999). This product is intended for research and analytical applications. Tiglic acid is a monocarboxylic unsaturated organic acid. Tiglic acid can be isolated from croton oil. Tiglic acid agonizes FFA2 and upregulates PYY expression. Tiglic acid derivatives have anti-inflammatory activity. Tiglic acid can be used in the research of obesity, diabetes, and inflammatory diseases.
    Tiglic acid (Standard)
  • HY-P11043
    GEP44
    		Inhibitor
    GEP44 is a peptide biased triple agonist targeting Glucagon-like peptide 1 receptor (GLP-1R), neuropeptide Y1 Receptor (Y1-R), and neuropeptide Y2 Receptor (Y2-R). GEP44 induces Y1-R antagonist-controlled, GLP-1R-dependent stimulation of insulin secretion in both rat and human pancreatic islets by counteracting effects of Y1-R and GLP-1R agonism. GEP44 promotes insulin-independent Y1-R-mediated glucose uptake in muscle tissue and significantly reduces food intake and body weight in diet-induced obese rat models. GEP44 can be used for obesity and type 2 diabetes mellitus research.
    GEP44
  • HY-P1132
    Galanin (1-29)(rat, mouse)
    		Agonist
    Galanin (1-29)(rat, mouse) is a non-selective galanin receptor agonist, with Kis of 0.98, 1.48 and 1.47 nM for GAL1, GAL2 and GAL3 respectively. Anticonvulsant effect.
    Galanin (1-29)(rat, mouse)
  • HY-145837
    Y1R probe-1
    Y1R probe-1 (Compound 39) is a high-affinity fluorescence probe for the Neuropeptide Y Y1 Receptor. Y1R probe-1 has the potential for the research of cancer disease.
    Y1R probe-1
  • HY-P1327
    BVD 10
    		Antagonist
    BVD 10, a neuropeptide Y (NPY) analogue peptide, is a highly selective NPY Y1 receptor antagonist. BVD10 significantly prevents NPY-induced glutamate increase. BVD 10 can be used for seizure research.
    BVD 10
  • HY-P1323
    [Leu31,Pro34]-Neuropeptide Y (human,rat)
    		Agonist
    [Leu31,Pro34]-Neuropeptide Y(human,rat) is a specific neuropeptide Y Y1 receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) slao activates Y4, Y5. [Leu31,Pro34]-Neuropeptide Y(human,rat) can increase blood pressure in anesthetized rats and increases food intake.
    [Leu31,Pro34]-Neuropeptide Y (human,rat)
  • HY-RS09512
    Npy1r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Npy1r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npy1r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Npy1r Mouse Pre-designed siRNA Set A
  • HY-P11291
    NNC0165-1273
    NNC0165-1273 is an analog of gut hormone peptide YY (PYY3-36). NNC0165-1273 has a superior affinity for Y2 receptor over Y1, Y4, and Y5 receptor. NNC0165-1273 has a potent anorectic effect and significantly reduces nighttime and ghrelin-induced food intake by producing early satiety. NNC0165-1273 inhibits ghrelin-induced cFos expression in NPY/AgRP neurons. NNC0165-1273 can be used for antiobesity therapies research.
    NNC0165-1273
Cat. No. Product Name / Synonyms Application Reactivity
Neuropeptide Y Receptor Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.